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Established Date: 1st July 2014
Reference Code: CoRe45/T5/2014/45/HW/5
Tier: 5
EK Star: 84.26 (5 Star)
This group is established to conduct on research related to bone and regenerative research for calcified tissue and associated disorders. This area of research is important as diseases related to bones and calcified tissue and their associated disorder are common in Malaysia such as osteoporosis and vascular calcification (advance stage of atherogenesis). Apart from that, this group has conducted research on osteosarcoma, the most common bone cancer. There is also a study on 3D culture model of osteosarcoma and the potential of nisin. In order to improve quality of life among these patients, we have investigated the effects of natural products such as black tea, green tea and phytoestrogens on osteogenesis and osteclastogenesis and hypothermia in metformin treated osteosarcoma cells and others. Among current research in this group are to study the effects of Bisphenol A (BPA) on bone mineralisation and the potential of isoflavones to overcome the effects of BPA and the ability of oxidized HDL in causing vascular calcification and osteoporosis. We would like to expand the effects of HDL dysfunction on epigenetics of atherosclerosis. This group also interested with study on metabolic diseases such as metabolic syndrome and diabetes mellitus. We have completed a study on effects of Pandan leaf extract in Metabolic syndrome rats.
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Associate Professor Dr. Suhaila Abd Muid |
| BMedSc. Hons (UKM), MSc (UiTM), PhD (UiTM) | |
| Head | |
| 603-6126 7318 | |
| suhaila_muid@uitm.edu.my | |
| Research Interest - Inflammation, vascular calcification, metabolic diseases, HDL dysfunction, dyslipidaemia, natural product |
 |
Dr Alyaa R. Mahmood Al-Khateeb |
| M.B.Ch.B (Mosul University Iraq), MSc (Mosul University Iraq), PhD (USM) | |
| Member | |
| 603-6126 7000 | |
| alyaa@uitm.edu.my | |
| Research Interest - Molecular Medicine, Bone Cancer, Familial Hypercholesterolaemia |
 |
Dr Aletza Mohd Ismail |
| MB BCh BAO (Belfast, UK), MPath (UM) | |
| Member | |
| 019-262 8134 | |
| aletza@uitm.edu.my | |
| Research Interest - Bone disorders, Metabolic syndrome, Quality in Laboratory Medicine |
 |
Dr Khor Goot Heah |
| BSc (Hons) (UM), MSc (UM), PhD (UM) | |
| Member | |
| 603-6126 6602 | |
| gootheah@uitm.edu.my | |
| Research Interest - Genomic, epigenetic, and microRNA studies in oral cancer, Effects of drug and herbal study on oral cancer |
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Dr Muhammad Fairuz Azmi |
| MBBCh BAO BMedSc (Ireland), MMedSc (UKM) | |
| Member | |
| 603-6126 7000 | |
| fairuz7677@uitm.edu.my | |
| Research Interest - Natural product |
 |
Dr Aisha Mohd Din |
| BSc. (Hons) Biomolecular Sciences (UiTM), PhD (Medicine) (UiTM) | |
| Member | |
| 012-6332456 | |
| aishamohddin@uitm.edu.my | |
| Research Interest - Osteosarcoma, Nanoparticles & Natural Products |
| 1 | Thent ZC, Froemming GR, Muid S (2019). Does Vitamin K Intake Influence High Phosphate Induced Vascular Pseudo-ossification: An Underappreciated Therapeutic Prospect in General Population? Current drug targets. 20(4):421-30. WOS Impact factor (2.951) , Scopus CiteScore 2.27. | - |
| 2 | Nur Hidayah Reshidan, Suhaila Abd Muid, Norshalizah Mamikutty (2019). The Effects of Pandanus Amaryllifolius (Roxb.) Leaf Water Extracts on Fructose-Induced Metabolic Syndrome Rat Model. BMC complementary and Alternative Medicine. 19 (1): 1-13. WOS Impact factor (2.479, Q2), SCOPUS CiteScore: 2.69. | - |
| 3 | Noor Hanisa Harun, Suhaila Abd Muid, Gabriele Fromming, and Hapizah Md Nawawi. Inflammation and vascular calcification causing effects of oxidised HDL are attenuated by adiponectin in human vascular smooth muscle cells. International Journal of Molecular and Cellular Medicine. 8(1): 39-54. WoS, Emerging Citation Source. SCOPUS, CiteScore: 1.72 | - |
| 4 | Muid S, Abu Bakar NA, Abdul Rahman T, Tengku Ismail TS, Kholin SF, Suvorov AV, Buravkova L, Nawawi H (2019). Effects of Prolonged Isolation in a Confined Space on Status of Oxidative Stress and Prothrombogenesis: In Preparation for Possible Future Manned Space Expedition to Mars. Malaysian Journal of Pathology. 41(3):283-292. SCOPUS. | - |
| 5 | Mohammed Ali Nashiry, Gabriele Ruth Anisah Froemming, Yeap Swee Keong, Aletza Binti Mohd Ismail, Aisha Mohd Din, Alyaa Mahmood Al-Khateeb (2019). Severe Hyperthermia Induces Apoptosis in Osteosarcoma Cells. The Indonesian Biomedical Journal. 2019, 11(2):167-174. (Scopus Indexed; Impact Factor: 0.290). Article Link: https://www.inabj.org/index.php/ibj/article/view/594 |  |
| 6 | Hassanain Al-Talib, Alyaa Alkhateeb, Ahmad Syahriza Ahmad Ruzuki, Nadia Farhana Zulkifli, Syakirah Hamizi, Nur Syazwani Muhammad and Amilah Fadhlina Abd Karim (2019). Effectiveness of commonly used antiseptics on bacteria causing nosocomial infections in tertiary hospital in Malaysia. African Journal of Microbiology Research | - |
| 7 | Noor Shafina Mohd Nor. Alyaa Mahmood Al-Khateeb. Yung-An Chua, Noor Alicezah Mohd Kasim and Hapizah Mohd Nawawi (2019). Heterozygous familial hypercholesterolaemia in a pair of identical twins: a case report and updated review. BMC Pediatrics. IF=1.9 | - |
| 8 | Mohammed Ali Nashiry, Alyaa Rajih Al-Khateeb, Aisha Mohd Din, Norita Salim, Aletza Mohd Ismail, Yeap Swee Keong & Gabriele Ruth Froemming (2019) . Mild Hyperthermia (39°C) Attenuates Berberine Chloride Cytotoxicity against Osteosarcoma Cells. Sains Malaysiana. 48(5):1097-1104. (ISI & Scopus Indexed; Impact Factor: 0.540). | |
| 9 | Al-Talib, H, Julia Ashazila, M.J., Hussaini, J.1, Wang, S.M., Mohd Shah, N.A., Al-Khateeb, A. and Chandrika, M (2019). A quadriplex PCR assay for rapid detection of diarrhea causing parasitic protozoa from spiked stool samples. Tropical Biomedicine IF= 0.719 | - |
| 10 | Comparing the effect of Nisin ZP on MG63 osteosarcoma cell viability using 2D and 3D culture models. Muhammad Fairuz Azmi , Sharaniza Abd Rahim , Alyaa Al-Khateeb , Effat Omar Abdul Rahman , Nurul Aimi Suryani Binti Badrol Hasni, Aisha Mohd Din, Gabriele R. A. Froemming (2019). Abstract in abstract book for Malaysian Anatomical Association Conference. | - |
| 11 | Khor Goot Heah, Nur Rawaidah Bt Mohd Shobri, Syairah Nabila Bt Suhaimi, Nurhanani Harun, Nur Aliana Hidayah Mohamed, Gabriele Ruth Anisah Froemming (2019). A review of microRNA associated with oral cancer. Journal of International Dental and Medical Research. 12(2): 738-743. Scopus Indexed. | - |
| 12 | Prabu Siva Sankar, Marimuthu Citartan, Aminah Ahmed Siti, Boris V Skryabin, Timofey S Rozhdestvensky, Goot Heah Khor, Thean Hock Tang (2019). A simple method for in-house Pfu DNA polymerase purification for high-fidelity PCR amplification. Iranian Journal of Microbiology. 11(2):181. Scopus Indexed. | - |
| 13 | Nyi Mas Siti Purwaningsih, Khor Goot Heah, Nik Mohd Mazuan Nik Mohd Rosdy, Effat Omar (2019). Immunohistochemical detection of Def6 protein in oral cancer. Malaysian Journal of Fundamental and Applied Sciences Vol. 15, No. 5 (2019) 699-702. Scopus Indexed. | |
| 1 | FRGS-RACER: The Efficacy Of Thymoquinone Nanoparticles And Hyperthermia On Modulating Chemoresistance Of Cancer Stem Cells In Osteosarcoma Principal Investigator: Aisha bt Mohd Din Amount: RM 51,200.00. Duration:1 Sept 2019 – 31 Aug 2021 |
| 2 | GIP: Underlying mechanism of oxidized high density lipoprotein and adiponectin in inducing osteoblast decalcification Principal Investigator: Suhaila Bt Abd Muid Amount: RM 20,000 Duration:1 July 2018 – 31 Aug 2019 |
| 3 | LESTARI: The Effects of Nisin on 3D Culture of Osteosarcoma MG-63: A Preliminary Study Principal Investigator: Dr Alyaa R. Mahmood Al-Khateeb Amount: RM 20,000. Duration:2018 – 2020 |
| 4 | BESTARI: Development Of New/Potential 3D Osteosarcoma Culture Model For Future Application In Translational Anti-Tumor Therapy. Principal Investigator: Dr Alyaa R. Mahmood Al-Khateeb Amount: RM 60,000. Duration: 2018 – 2020 |
| 5 | FRGS 2018 & 2019: Analysis of Promoter Methylated Genes Associated WNT Signaling Pathway in Human Oral Squamous Cell Carcinoma Principal Investigator: AP Dr Khor Goot Heah Amount: RM 183,300. Duration:2018 – 2020 |
| 1 | Siti Shuhada Mokhtar, Noor Hanisa Harun, Gabriele Ruth Anisah Froemming, Aletza Mohd Ismail, Suhaila Abd Muid • Best Paper Award, 6th International Conference on Science & Social Research (Penang, Malaysia) |
| 2 | Suhaila Abd Muid (Co-PI) • ITEX 2019 Gold Medal |
| 3 | Aisha bt Mohd Din • IIDEX 2019 Award (Gold medal), UiTM 2019. |
| 1 | Aisha bt Mohd Din Title of copyright: Cell Spotting: A Technique For 3d Osteosarcoma Culture System. Copyright number: E.g. CRLY00018948 |
| 1 | Research collaboration with Universiti Putra Malaysia |
| 2 | Research collaboration with Spine and Joint, Sri Hartamas |
| 3 | Research collaboration with Schools: SK Sri Langat, SJK (C) Kah Wah, SJK (T) Telok Datok; Banting, Selangor. |
