Department of Biochemistry & Molecular Medicine

INTRODUCTION

The study of Biochemistry and Molecular Medicine in the MBBS curriculum is of paramount importance as it deals with the biochemical processes in living things with emphasis on the basic knowledge of molecular biology. It is a pivotal foundation for the medical students in becoming highly motivated and accomplished medical professionals. Respectively, members of the Biochemistry and Molecular Medicine department aspire in delivering the knowledge to the pre-clinical students to our best effort and commitment.
In line with the vision of the faculty in promoting research, members of the department has and continues to contribute toward the research development in the faculty. Research findings covering various research area including endocrinology, cancers, natural products, nutrition and molecular virology have been published in numerous indexed and peer-reviewed journals in addition to many awards of recognitions from the scientific community. Very much so, members of the department will always aspire toward excellence both in teaching as well as in research.

Members of Department of Biochemistry & Molecular Medicine

mudiana
Dr. Mudiana Muhammad
Bsc.(Hons)(UM),
MSc(UM),
PhD(UM)
musalmah
Prof. Dr. Musalmah Mazlan
Bsc.(Surrey),
MSc.(Newcastle-Upon Tyne),
PhD(London)
Jemine
Assoc. Prof. Dr. Jesmine Khan
MBBS(Bangladesh),
PhD (Osaka)
Narimah
Assoc. Prof. Dr. Narimah Abdul Hamid Hasani
Bsc.Hons.(UM),
PhD(UKM)
Alya
Dr. Alya R. Mahmood Al-Khateeb
MBBS(Iraq),
MSc.(Iraq),
PhD(USM)
Johari
Dr. Mohammad Johari Ibrahim
Bsc.(UKM),
MSc.(UKM),
PhD(Melbourne)
Sharaniza
Dr. Sharaniza Ab. Rahim
Bsc.(UM),MSc.(UM),
PhD(UM)
Hamimah
Dr. Siti Hamimah Sheikh Abdul Kadir
Bsc.(UPM),
MSc.(Sheffield),
PhD(Imperial College)
suhaila
Dr. Suhaila Abd. Muid
Bsc.(UKM),MSc.(UiTM),
PhD(UiTM)
wang
Dr. Wang Seok Mui
Bsc.(RMIT),
MSc.(UNIMAS),
PhD(UNIMAS)
izzah
Dr. Wan Nor I'zzah Wan Mohamad Zain
Bsc.(Adelaide)MSc.(UPM),
PhD(UPM)
shuhada
Ms. Siti Shuhada Mokhtar
Dip.Sc(UiTM), Bsc.(UiTM),
MSc.(UiTM)
amirah
Dr. Amirah Abd. Rahman
Bsc.Hons(UKM),MSc.(UKM),
PhD(UKM)

RESEARCH PROJECTS

Prof. Dr. Musalmah Mazlan(PI)
Cancer Metabolome: Discovering and understanding cancer metabolites for early detection and prognostication. 2015-2020. LRGS

Assoc. Prof. Dr. Jesmine Khan(PI)
Possible mechanism of higher uptake of particles by the gut associated lymphoid tissue and Peyer’s patches of rats fed high fat diet Part 1. Nov 2013-June 2016. FRGS

Assoc. Prof. Dr.Narimah Abd. Hamid Hasani(PI)
Cloning and characterization of cyclotides genes from the local plants, Leucaena leucocephala and Parkia speciose.2016-2018. FRGS

Dr. Mudiana Muhamad @ Mohd. Saufi(PI)
Investigation of the Mechanism of Human Norovirus (HuNoV) Host Cell Entry in M Cells 3D Culture System Via Binding To Toll-Like Cell Surface Receptors. Nov 2015-Oct 2018. FRGS

Dr. Sharaniza Ab. Rahim(PI)
Mechanism of osteosarcoma stem cells (ossc)reverse differentiation into normal osteogenic cells by bone morphogenic proteins (BMPs). Aug 2016-July 2019. FRGS

The Role of Integrin Glycosylation on the Adhesion of the Primary Cultured Osteosarcoma (OS) Cells to the Extracellular Matrix during Metastasis. May 2016-Apr 2018. LESTARI RIG: Research Bone Group. May 2016-Apr 2018. REI

Dr. Siti Hamimah Sheikh Abdul Kadir(PI)
Understanding the role of miRNA in cardiac reprogramming of fetus exposed to BPA during in utero life. 2016-2019. FRGS

Dr. Muhammad Johari Ibahim(PI)
Investigating the Role of Eosinophils in the Progression of Breast Cancer in Mouse Model Post-Radiotherapy Treatment. 2016-2019. FRGS

Dr. Wang Seok Mui(PI)
Antiviral activity of 1-substituted 5-(phenylamino) uracil derivatives against chikungunya virus .Sept 2016-Aug 2018. LESTARI Antiviral activity of porcupine bezoar against dengue virus.Sept 2016 – Aug 2018.BESTARI

Dr. Suhaila Abd. Muid(PI)
Underlying mechanisms of oxidised high density lipoprotein (oxHDL) and adiponectin in inducing vascular calcificationand abrogation of osteoblast function. 2015-2018. FRGS

 

PUBLICATIONS

Amin IM, Sheikh Abdul Kadir SH, Isa MR, Rosdy NMMNM, Hasani NAH.Mechanisms of aloe emodin-induced apoptosis in ER+ breast cancer cells, MCF-7. Pertanika Journal, in press. [SCOPUS]

Muid, S., Froemming, G.R.A., Rahman, T.H., Ali, A.M. and Nawawi, H. Tocotrienols reduce monocytes adhesion to stimulated human endothelial cells. International Food Research Journal (December 2017) 24(6): 2580-2585 [SCOPUS].

Noorfaiza A. Aziz, Gabriele Ruth Anisah Froemming, Siti Hamimah Sheikh Abdul Kadir, Mohammad Johari Ibrahim. Apigenin Increases Cisplatin Inhibitory Effects On The Telomerase Activity Of Triple Negative Breast Cancer Cells. Jurnal Teknologi (2018) 80 (1): 123 -132 [ISI/SCOPUS]

Narimah Abdul Hamid Hasani, Indah Mohd Amin, Roziana Kamaludin, Nik Mohd Mazuan Nik Mohd Rosdyd, Mohammad Johari Ibahim, Siti Hamimah Sheikh Abdul Kadir. P53 And Cyclin B1 Mediate Apoptotic Effects Of Apigenin And Rutin In Era+-Breast Cancer Mcf-7 Cells. Jurnal Teknologi (2018) 80 (1):133 - 140 [ISI/SCOPUS]

Anis Syamimi Mohamed, Noorul Izzati Hanafi, Siti Hamimah Sheikh Abdul Kadir, Julina Md. Nor, Narimah Abdul Hamid Hasani, Sharaniza Ab. Rahim, Rosfaiizah Siran. Ursodeoyxcholic acid protects cardiomyocytes against cobalt chloride induced hypoxia by regulating transcriptional mediator of cells stress hypoxia inducible factor 1α and p53 protein (2017) Cell Biochemistry and Function 1-11. [ISI/SCOPUS IF 2.186]

Jesmine Khan, Mohammed Nasimul Islam. Intestinal Tight Junction Proteins: Possible Modulation by Zinc (2017) International Medical Journal Vol. 24, No. 5, pp. 371 - 374 [SCOPUS].

Musalmah Mazlan, Hamizah Shahirah Hamezah, Nursiati Mohd Taridi, Yu Jing, Ping Liu, Hu Zhang, Wan Zurinah Wan Ngah, and Hanafi Ahmad Damanhuri. Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats. Oxidative Medicine and Cellular Longevity. Volume 2017 (2017), Article ID 6019796, 13 pages. https://doi.org/10.1155/2017/6019796 [ISI/SCOPUS IF 4.593]

Abdul Rais Sanusi, Alicezah Mohd Kasim, Azhari Rosman, Hapizah Nawawi, Nadzimah Mohd Nasir, Radzi Rahmat, Rohana Abdul Ghani, Sazzli Kasim, Suhaila Muid, Suraya Abdul-Razak, Thuhairah Abdul Rahman, Zaliha Ismail, Zubin Ibrahim. Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population (2017) BMC Cardiovascular Disorders 17 (1), 264 [ISI/SCOPUS IF 1.832]

S Muid, YA Chua, WN Yusoff, GRA Froemming, A Manaf, H Nawawi. High-density lipoprotein attenuates secretion and gene expression of cellular adhesion molecules and proinflammatory cytokines in lipopolysaccharide-stimulated endothelial cells. Journal of Fundamental and Applied Sciences 9 (6S), 316-330 [SCOPUS]

WNW Yusoff, NAA Bakar, S Muid, AM Ali, GRA Froemming, H Nawawi. Antioxidant activity of high-density lipoprotein (hdl) using different in vitro assays. Journal of Fundamental and Applied Sciences 9 (6S), 298-315 [SCOPUS]

S Muid, YA Chua, WN Yusoff, GRA Froemming, A Manaf, H Nawawi. High-density lipoprotein attenuates secretion and gene expression of cellular adhesion molecules and proinflammatory cytokines in lipopolysaccharide-stimulated endothelial cells. Journal of Fundamental and Applied Sciences 9 (6S), 316-330 [ISI/SCOPUS]

Nik Nairan Abdullah, Suzanna Daud, Seok Mui Wang, Zamalia Mahmud, Noor Kaslina Mohd Kornain, and Waqar Al-Kubaisy. Human Papilloma Virus (HPV) self-sampling: do women accept it? Journal of Obstetrics and Gynaecology https://doi.org/10.1080/01443615.2017.1379061 [ISI/SCOPUS IF 0.629]

Zailani MZ, Ismail AF, Siti Hamimah Sheikh Abd Kadir, Othman MHD, Goh PS, Hasbullah H, Abdullah MS, Ng BC and Kamal F. Hemocompatibility Evaluation of Poly (1,8-octanediol citrate) Blend Polyethersulfone Membranes.Journal of Biomedical Materials Research:Part A

Hanafi NI, Siti Hamimah Sheikh Abd Kadir, Mohamed AS, Md Noor J, Osman NJ, Siran R, Sharaniza Ab. Rahim and Narimah Abd Hamid Hasani. Ursodeoxycholic acid regulates caspase-9 and ros production in protecting cardiomyocytes against hypoxia. Jurnal Teknologi

Hepato renal lesion in long term exposure to Arsenic trioxide and their reversibility. SS Shahidan, E Omar, Jesmine Khan, MN Islam. International Medical Journal 2017, 24(1), 67-70

Hassanain Al-Talib, Alyaa Al-Khateeb, Ayad Hameed and Chandrika Murugaiah. Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris. An Bras Dermatol. 2017

Japanese encephalitis virus disrupts blood-brain barrier and modulates apoptosis proteins in THBMEC cells. Mazen M, Jamil Al-Qbaidi, Azadeh Bahadoran, Lee Sau Har, Wang Seok Mui, Jayakumar Rajarajeswaran, Keivan Zandi, Rishya Manikam, Shamala Devi Sekeran. Virus Research 2017 (233), p17-28

Abdul Nasir NA, Agarwal R, Sheikh Abdul Kadir SH, Vasudeven S, Tripathy M, Iezhitsa I, Mohammad Daher A, Ibrahim MI, Mohd Ismail N. Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats. PLOS ONE. 2017. Epub at https://doi.org/10.1371/journal.pone.0174542

Zainal Abidin MN, Goh PS, Ismail AF, Othman MHD, Hasbullah H, Said N, Sheikh Abdul Kadir SH, Kamal F, Abdullah MS, Ng BC. Development of biocompatible and safe polyethersulfone hemodialysis membrane incorporated with functionalized multi-walled carbon nanotubes. Materials Science And Engineering: C.2017. 77. 572–582.

Kamaludin R, Othman MHD, Sheikh Abdul Kadir SH, A Rahman M, Jaafar J. The morphological properties study of photocatalytic TIO2/PVDF dual layer hollow fibre membrane for Endocrine Disrupting compounds degradation. 2017. Malaysian Journal of Analytical Science. 21 (2). 426-434.

Said N, Hasbullah H, Ismail AF, Zainal Abidin MN, Goh PS, Othman MHD, Sheikh Abdul Kadir SH, Kamal F, Abdullah MS, Ng BC. The Effect of Air Gap on the Morphological Properties of PSf/PVP90 Membrane for Hemodialysis Application. Chemical Eng Transcations. 2017. 56, 1591-1596 DOI:10.3303/CET1756266

Said N, Hasbullah H, Ismail AF, Othman MHD, Goh PS, Zainal Abidin MN, Sheikh Abdul Kadir SH, Kamal F, Abdullah MS, Ng BC. Enhanced hydrophilic polysulfone hollow fiber membranes with addition of IONPs nano-fillers. Polymer International. 2017.DOI: 10.1002/pi.5401

 

CONTACTS

For general enquiries please contact;

Dr. Mudiana Muhamad Saufi (Head of Department)

mudiana_muhamad@salam.uitm.edu.my

03-6126 7360

Address : Faculty of Medicine

               Universiti Teknologi MARA (UiTM)

               Sg. Buloh Campus

               Jln Hospital, 47000, Sg. Buloh,

               Selangor Darul Ehsan,

               MALAYSIA